Clean-in-place (CIP) is a widely used technique applied to clean industrial equipment without disassembly. Cleaning protocols are currently defined arbitrarily from offline measurements. This can lead to excessive resource (water and chemicals) consumption and downtime, further increasing environmental impacts. An optical monitoring system has been developed to assist eco-intelligent CIP process control and improve resource efficiency. The system includes a UV optical fouling monitor designed for real-time image acquisition and processing. The output of the monitoring is such that it can support further intelligent decision support tools for automatic cleaning assessment during CIP phases. This system reduces energy and water consumption, whilst minimising non-productive time: the largest economic cost for CIP.